NATURAL HISTORY OF A MOUSE MODEL OF X-LINKED MYOTUBULAR MYOPATHY

Natural history of a mouse model of X-linked myotubular myopathy

X-linked myotubular myopathy (XLMTM) is a severe monogenetic disorder of the skeletal muscle.It is caused by loss-of-expression/function mutations in the myotubularin (MTM1) gene.Much of what is known about the disease, skin oil as well as the treatment strategies, has been uncovered through experimentation in pre-clinical models, particularly the

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C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria.

Placental malaria (PM) is a leading cause of maternal and infant mortality.Although the accumulation of parasitized erythrocytes (PEs) and monocytes within the placenta is thought to contribute to the pathophysiology of PM, the molecular mechanisms underlying PM remain unclear.Based on the hypothesis that excessive complement activation may contrib

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Effect of Feeding Different Cultivars of Leucaena leucocephala on Rumen-Based in vitro Anaerobic Fermentations

The leguminous forage shrub, Leucaena leucocephala, is one of the few nutritional options available to significantly improve beef productivity in Northern Australia.A mixed bacterial rumen inoculum for the detoxification of mimosine (present in Leucaena) and its toxic derivatives 3,4 DHP and 2,3 DHP has been produced in an anaerobic fermenter for t

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The foundation of a nerve-based economy

Selection and decision making is one of the most important current trends in economics theory.Neuroscience economics science toy is a subset of behavioural economics that uses empirical evidence such as computational constraints, willpower, and greed to inspire new economic theories.It also studies different parts of the brain that analyse Honey Ja

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